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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: miR-146a-5p-modified hUCMSC-derived exosomes facilitate spinal cord function recovery by targeting neurotoxic astrocytes

Fig. 5

miR-146a-5p-modified exosomes reduced toxicity of neurotoxic astrocytes in vivo. a Representative immunostaining images of C3(green)/GFAP (red) in rats of SCI (the SCI group), SCI rats treated with ExoN and ExoOE (the SCI + ExoN group and the SCI + ExoOE group) 3dpi, 5dpi, 7dpi and 14 dpi (detailed regions where the representative image selected from are provided in Additional file 10) Scale bar = 20 μm. b Quantification of the mean immunofluorescence intensity of C3 in rats with SCI at 3rd, 5th, 7th and 14th dpi. c, d Mean immunofluorescence intensity of C3 in rats of three groups at 3dpi 5dpi, 7dpi and 14 dpi. e, f Representative images and quantitative analysis of TUNEL staining in rats of SCI, SCI + ExoN and SCI + ExoOE group at 3dpi. Scale bar = 100 μm. Data above are represented as mean ± SD. *, p < 0.05; **, p < 0.01. #, p > 0.05

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Stem Cell Research & Therapy

ISSN: 1757-6512