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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: miR-146a-5p-modified hUCMSC-derived exosomes facilitate spinal cord function recovery by targeting neurotoxic astrocytes

Fig. 6

miR-146a-5p-modified exosomes promoted the functional recovery of rats with SCI. a BBB scores of rats in three groups on the 1st, 3rd, 5th, 7th, 14th, 21st, 28th dpi (n = 10/group). b Representative footprints of rats walking in 28th dpi in each group and quantification of the footprints analysis. c, d Quantitative analysis and representative MRI images of the lesion area of rats in each group at 28th dpi. Scale bar = 5 mm e Representative immunostaining images of MAP2 (green) /GFAP (red) in spinal cord tissue of each group at 28th dpi. Scale bar = 500 μm. f Representative images of the lesion size (HE staining) in the three groups of rats at 28th dpi. Scale bar = 1000 μm Data above are represented as mean ± SD. *, p < 0.05; **, p < 0.01

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