Emerging role of mesenchymal stromal cells (MSCs)-derived exosome in neurodegeneration-associated conditions: a groundbreaking cell-free approach

Yari, Hadi; Mikhailova, Maria V.; Mardasi, Mahsa; Jafarzadehgharehziaaddin, Mohsen; Shahrokh, Somayeh; Thangavelu, Lakshmi; Ahmadi, Hosein; Shomali, Navid; Yaghoubi, Yoda; Zamani, Majid; Akbari, Morteza; Alesaeidi, Samira

doi:10.1186/s13287-022-03122-5

Stem Cell Research & Therapy

Table 2 MSCs-derived secretome (e.g., exosome) therapy in preclinical models of chronic neurodegenerative diseases

From: Emerging role of mesenchymal stromal cells (MSCs)-derived exosome in neurodegeneration-associated conditions: a groundbreaking cell-free approach

Condition	Model	Cell source	Administration route	Results	Ref
AD	Mice	BM	Intranasal	Stimulation of neuroprotection in part through inhibition of neuroinflammation	[99]
AD	Mice	BM	Intravenous	Attenuation of Aβ levels and provoking anti-inflammatory impact leading to the amelioration of learning and memory functions	[261]
AD	Mice	BM	Intravenous	Reducing cognitive deficits through exosomal miR-146a	[262]
AD	Rat	BM	Intravenous	Induction of neurogenesis	[263]
MS	Mice	PDL	Intravenous	Inhibition of NLRP3 inflammasome activation	[189]
MS	Mice	BM	Intravenous	Attenuation of demyelination lesion area and reducing diseases severity	[186]
MS	Mice	BM	Intravenous	Triggering remyelination and attenuation of the neuroinflammation	[198]
MS	Mice	BM	Intravenous	Reducing diseases severity by HGF delivery	[201]
MS	Mice	AT	Intravenous	Improving the Tregs population and IL-4 levels	[264]
MS	Mice	PDL	Intravenous	Improving IL-37 expression causing down-regulation of the pro-inflammatory cytokines levels	[265]
MS	Mice	SHEDs	Intravenous	Attenuation of demyelination and axonal injury, inhibition of inflammatory cell infiltration and also promoting M2/M1 macrophage ratio	[266]
PD	Rat	BM	Intravenous	Reducing the deterioration of DA neuron in SN and thus promoting dopamine levels in striatum	[100]
PD	Rat	BM	Intravenous	Induction of the protective effect on DA neuron	[101]
PD	Mice	AT	Intravenous	Mitigation of autophagy and pyroptosis	[233]
PD	Mice	AT	Intraperitoneal	Eliciting the HBMECs angiogenesis	[102]
PD	Rat	AT	Intravenous	Exerting antioxidant effects by improving sirtuin 3 levels	[267]
PD	Rat	BM	Intravenous	Amelioration of motor activities	[268]
PD	Rat	BM	Intranigral Intrastriatal	Promoting neural plasticity	[269]
PD	C. elegans	BM	NA	Decreasing α-syn aggregates in striatum	[228]
HD	Mice	AM	Intraperitoneal	Amelioration of motor functions	[270]
ALS	Mice	AT	Intravenous Intranasal	Down-regulation of glial cells function, favoring motor neurons, and eliciting protective effect on neuromuscular junctions (NMJs)	[271]

MSCs mesenchymal stromal cells, AD Alzheimer’s disease, PD Parkinson’s disease, ALS amyotrophic lateral sclerosis, HD Huntington’s disease, MS multiple sclerosis, BM bone marrow, AT adipose tissue, PDL periodontal ligament, Aβ amyloid beta-peptide, AM amniotic membrane, NLRP3 NLR family pyrin domain containing 3, HBMECs human brain microvascular endothelial cells, FOXP3 forkhead box P3, α-syn alpha-synuclein, SHED stem cells from human exfoliated deciduous teeth, NA not applicable

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ISSN: 1757-6512

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