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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: iPSCs derived from insulin resistant offspring of type 2 diabetic patients show increased oxidative stress and lactate secretion

Fig. 2

iPSCs derived from insulin-resistant offspring of T2D patients and insulin-sensitive individuals can differentiate to all germ layers. A Immunostaining analysis for the three germ layer markers; endoderm (SOX17), ectoderm (NESTIN) and mesoderm (BRACHYURY, VIMENTIN) in spontaneously differentiated embryoid bodies (EBs) from the generated iPSCs. B Scorecard analysis results for mRNA of representative IS and IR-iPSCs that were spontaneously differentiated as EBs showing downregulation of pluripotency markers and increased expression of the three lineage markers

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Stem Cell Research & Therapy

ISSN: 1757-6512