Skip to main content
Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Fat transplantation induces dermal adipose regeneration and reverses skin fibrosis through dedifferentiation and redifferentiation of adipocytes

Fig. 4

Assessment of the therapeutic effect of adipose-derived cells on BLM-induced fibrotic skin. A Study design of transplantation with adipose-derived cells for the treatment of fibrotic skin in mice. B Before transplantation of the fluorescent cells into the mice, they were stained with Calcein/PI to assess cellular viability. C Tdtomato immunofluorescent staining of skin lesion after transplantation in vivo. D MT staining of skin lesion. E Measurement of dermal thickness. F Semi-quantitative analysis of collagen density. G Semi-quantification of the number of sebaceous glands. H Semi-quantification of the number of hair follicles. I Perilipin staining of skin lesion after transplantation in vivo showed adipocyte accumulation in the skin. J Semi-quantification of the number of adipocytes. K qRT-PCR analysis of PPAR-γ transcription showed enhanced adipogenesis in DA and adipocyte groups (*p < 0.05; **p < 0.01, n = 5)

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512