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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Fat transplantation induces dermal adipose regeneration and reverses skin fibrosis through dedifferentiation and redifferentiation of adipocytes

Fig. 7

The effect of ASCs, DAs and adipocytes on scleroderma fibroblasts and M1/M2 macrophage polarization. Quantitative PCR analysis of various gene expressions in human scleroderma fibroblasts (hSF) without or with co‐culture of ASCs, DAs or adipocytes, respectively, for α‐SMA (A), TGF-β1 (B), collagen I (C), collagen III (D) and fibronectin (E). mRNA expression levels of iNOS (F), TNF-α (G) and IL-6 (H) in BMDMs, which were treated with or without LPS and were co-cultured with or without ASCs, DAs or adipocytes. mRNA expression levels of CD206 (I), Arg-1 (J), and IL-10 (K) in BMDMs, which were treated with or without IL-4 and were co-cultured with or without ASCs, DAs or adipocytes (*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001, n = 5)

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Stem Cell Research & Therapy

ISSN: 1757-6512