Fig. 7

BM-MSC transplants alter the profile of pro- and anti-inflammatory cytokines in the retina, but do not cause retinal ganglion cell death. A Column graphs showing the mean concentration (pg/ml) ± SD of tumour necrosis factor α (TNF-α), interleukin 6 (IL-6), prostaglandin E2 (PGE2) and transforming growth factor β (TGFβ) in retinal extracts from all groups analysed at 21 days after each transplant. *Significant compared to intact values (*p < 0.05, **p < 0.01), ^ƟSignificant comparing non-immunosuppressed with immunosuppressed (^Ɵp < 0.05), ^ψSignificant comparing xeno- and allotransplants with syngeneic transplants (^ψp < 0.05). Nonparametric Mann–Whitney t test. n = 4 retinas/group and 3 replicates/plate. B: Top: isodensity maps showing the topography of RGCs in transplanted retinas analysed 21 days after each transplant. Below each map is shown the total number of RGCs counted in its corresponding retina. Middle: magnifications showing Brn3a⁺RGCs in flatmounts. Bottom: column graph showing the mean total number of RGCs ± SD in each group. n = 6 animals/group