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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Knockdown of FOXA1 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells partly via activation of the ERK1/2 signalling pathway

Fig. 3

FOXA1 overexpression decreased the osteo-specific gene and protein levels, inhibited the ERK1/2 signalling pathway. A The mRNA expression levels (normalised to that of 18S) of FOXA1, COL1A1, RUNX2, SP7, OPN in FOXA1 OE-NC and FOXA1 OE groups after 3 and 7 days of osteogenesis. B, C The protein expression levels (normalised to that of GAPDH) of FOXA1, COL1A1, RUNX2 and SP7 in FOXA1 OE-NC and FOXA1 OE groups after 3 and 7 days of osteogenesis. D, E The level of p-ERK1/2 (normalised to that of ERK1/2) decreased after 3 and 7 days of osteogenesis in FOXA1-OE group. All data are means ± SDs (n = 3). *p < 0.05, **p < 0.01, and ***p < 0.001 versus the control group

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Stem Cell Research & Therapy

ISSN: 1757-6512