Fig. 7
Abstract figure and proposed mechanism of action of the selected miRNAs influencing the hiPSC-CM proliferation–maturation axis. Representative model of action associated with all miRNAs analyzed A and miR-124 B regarding different maturation features analyzed that occur over time. C Schematic of miR-124-3p action in modulating Calcium transient by targeting genes associated with plasma membrane calcium channels, sarcoplasmic reticulum (SR) channels, and Ca2+ buffering-associated proteins. In the figure, green rounded arrows indicate that we accessed gene expression and found no alterations. Flat-tipped and green arrows indicate possible interactions of miR-124-3p with predicted and validated genes. Flat-tipped and yellow arrows indicate that RYR2 protein function was reduced after miR-124-3p treatments. D Scheme of miR-124-3p action on genes regulating different phases of the action potential. Red colors indicate that the interaction with the gene is predicted, while green colors indicate validated interactions. The graphical abstract was created with Mind the Graph