Table 1 Stratified meta-analysis for mNSS
From: Efficacy of stem cell therapy in animal models of intracerebral hemorrhage: an updated meta-analysis
Categories | No. of comparisons | Pooled SMD (95% CI) | p-value | Heterogeneity test | Between groups p-value | ||
|---|---|---|---|---|---|---|---|
Q statistics | I2(%) | pQ-value | |||||
Species | 0.382 | ||||||
 Rats | 39 | − 2.14 (− 2.56, − 1.72) | < 0.001 | 162.03 | 76.55 | < 0.001 |  |
 Mice | 8 | − 2.81 (− 3.79, − 1.84) | < 0.001 | 53.85 | 87 | < 0.001 |  |
 Monkey | 2 | − 2.88 (− 4.87, − 0.89) | 0.005 | 0.001 | 0 | 0.982 |  |
Quality | 0.013* | ||||||
 High (score ≥ 5) | 35 | − 2.57 (− 3.01, − 2.13) | < 0.001 | 144.37 | 76.45 | < 0.001 |  |
 Low (score < 5) | 14 | − 1.59 (− 2.22, − 0.96) | < 0.001 | 52.02 | 75.01 | < 0.001 |  |
Methods of ICH | 0.196 | ||||||
 Autologous blood | 14 | − 1.78 (− 2.47, − 1.09) | < 0.001 | 27.86 | 53.33 | 0.009 |  |
 Collagenase | 34 | − 2.46 (− 2.92, − 2.00) | < 0.001 | 189.08 | 82.55 | 0.00 |  |
 Hemoglobin | 1 | − 3.53 (− 6.44, − 0.62) | 0.018 | 0.00 | 0.00 | 1.00 |  |
Delivery routes | 0.002* | ||||||
 Intra-arterial | 7 | − 1.91 (− 2.80, − 1.01) | < 0.001 | 37.65 | 84.06 | < 0.001 |  |
 Intracerebral | 22 | − 2.72 (− 3.25, − 2.19) | < 0.001 | 74.08 | 71.65 | < 0.001 |  |
 Intraperitoneal | 2 | − 4.63 (− 6.46, − 2.80) | < 0.001 | 0.84 | 0.00 | 0.361 |  |
 Intravenous | 18 | − 1.61 (− 2.15, − 1.07) | < 0.001 | 54.88 | 69.02 | < 0.001 |  |
Sources of stem cells | 0.211 | ||||||
 Allogeneic | 24 | − 2.50 (− 3.05, − 1.94) | < 0.001 | 141.69 | 83.77 | < 0.001 |  |
 Syngeneic | 3 | − 3.16 (− 4.81, − 1.51) | < 0.001 | 19.32 | 89.65 | < 0.001 |  |
 Xenogeneic | 22 | − 1.94 (− 2.50, − 1.38) | < 0.001 | 57.57 | 63.53 | < 0.001 |  |
Types of stem cells | 0.622 | ||||||
 BM-EPCs | 1 | − 1.85 (− 4.36, 0.67) | 0.150 | 0.00 | 0.00 | 1.00 |  |
 IPSCs | 1 | − 3.83 (− 6.48, − 1.18) | 0.005 | 0.00 | 0.00 | 1.00 |  |
 MSCs | 40 | − 2.20 (− 2.62, − 1.78) | < 0.001 | 168.85 | 76.90 | < 0.001 |  |
 NSCs | 7 | − 2.52 (− 3.54, − 1.50) | < 0.001 | 42.61 | 85.92 | < 0.001 |  |
Time administration | 0.667 | ||||||
 [0–8 h] | 13 | − 2.48 (− 3.26, − 1.71) | < 0.001 | 33.78 | 64.48 | 0.001 |  |
 24 h | 15 | − 1.88 (− 2.57, − 1.20) | < 0.001 | 49.49 | 71.71 | < 0.001 |  |
 (1 days–7 days] | 15 | − 2.33 (− 3.03, − 1.63) | < 0.001 | 80.46 | 82.60 | < 0.001 |  |
 > 1 week | 5 | − 2.78 (− 4.05, − 1.51) | < 0.001 | 44.30 | 90.97 | < 0.001 |  |
 NR | 1 | − 2.85 (− 5.33, − 0.38) | 0.024 | 0.00 | 0.00 | 1.00 |  |
Doses of stem cells | 0.914 | ||||||
 < 1 × 106 | 16 | − 2.29 (− 2.97, − 1.62) | < 0.001 | 39.57 | 62.10 | 0.001 |  |
 [1–5] × 106 | 30 | − 2.32 (− 2.81, − 1.83) | < 0.001 | 175.22 | 83.45 | < 0.001 |  |
 > 5 × 106 | 2 | − 1.68 (− 3.52, 0.17) | 0.075 | 1.04 | 3.99 | 0.307 |  |
 NR | 1 | − 1.87 (− 4.62, 0.87) | 0.181 | 0.00 | 0.00 | 1.00 |  |