Fig. 4

Changes in plasma Hp concentrations after BMT in mice with severe radiation injury. A Schematic to describe transplantation of whole bone marrow (WBM) into lethally irradiated recipients. BMT, bone marrow transplantation. B Survival rate, Lymphocyte count in irradiated mice. The P value of survival rate determined by log-rank (Mantel-Cox) test. C Hp was measured using ELISA in 0 Gy, 0 Gy + T, 10 Gy, 10 Gy-1d-T, 10 Gy-3d-T-1, 10 Gy-3d-T-2, 10 Gy-5d-T-1, 10 Gy-5d-T-2, 10 Gy-5d-T-3, irradiated female C57BL/6J mice at different time points. Data are mean ± SD of n = 6 mice per group except 10 Gy-3d-T-2 (n = 5), statistical significance by Student’s t-test. *, P < 0.05; **, P < 0.01; ****, P < 0.0001. Additional file 1: Table S4 shows the P value of Hp concentrations after comparing with the previous time point. D Comparison of lymphocytes and Hp in 10 Gy, 10 Gy-1d-T, 10 Gy-3d-T-2, 10 Gy-5d-T-3, irradiated female C57BL/6J mice at different time points. Data are mean ± SD of n = 6 mice per group except 10 Gy-3d-T-2 (n = 5), statistical significance by Student’s t-test. *, P < 0.05; **, P < 0.01. T transplantation, A amifostine, Hp haptoglobin