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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Effects of hypoxia-preconditioned HucMSCs on neovascularization and follicle survival in frozen/thawed human ovarian cortex transplanted to immunodeficient mice

Fig. 5

A Total endothelial area by CD31 immunohistochemistry to evaluate the percent of the vessel-covered area. B Total endothelial area by CD34 immunohistochemistry to evaluate the percent of the vessel-covered area. C The percentage of Ki67 (+) primordial follicles was evaluated in grafts. Histological features of human ovarian tissues in the grafts of ovarian tissue evaluated with immunohistochemistry staining for CD31, CD34, and Ki67. CD31 and CD34 were represented as mean ± SEM and analysed by one-way ANOVA and Fisher’s LSD post hoc test. Ki67 was represented as mean ± SEM and analysed by the Kruskal–Wallis and Fisher’s post hoc tests. Scale bars: 50 μm. P value references: *P < 0.05; ***P < 0.001. OT, ovarian tissue transplantation; N-MSCs + OT, normoxic-treated HucMSCs, and ovarian tissue co-transplantation. H-MSCs + OT, hypoxia-treated HucMSCs, and ovarian tissue co-transplantation. n = 4 per group and per time point

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Stem Cell Research & Therapy

ISSN: 1757-6512