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Table 3 Univariate analysis of the OS, PFS, TRM, and relapse rate in all patients

From: Unrelated umbilical cord blood can improve the prognosis of haploidentical hematopoietic stem cell transplantation

Variable

OS

PFS

TRM

Relapse

HR (95%CI)

P value

HR (95%CI)

P value

HR (95%CI)

P value

HR (95%CI)

P value

Age

1.030 (1.002–1.058)

0.036

1.839 (1.037–3.259)

0.037

1.692 (0.885–3.237)

0.112

1.706 (0.689–4.223)

0.248

Gender

0.089 (0.340–1.922)

0.631

0.859 (0.390–1.894)

0.707

0.782 (0.314–1.947)

0.597

1.071 (0.309–3.713)

0.914

Height

1.213 (0.512–2.876)

0.660

0.829 (0.371–1.850)

0.646

1.207 (0.487–2.991)

0.685

0.538 (0.138–2.099)

0.373

Weight

1.162 (0.489–2.758)

0.734

1.410 (0.633–3.144)

0.401

0.971 (0.395–2.391)

0.950

2.259 (0.582–8.769)

0.239

Disease status

1.500 (0.957–2.351)

0.077

1.527 (1.015–2.295)

0.042

1.303 (1.047–1.621)

0.018

1.815 (0.951–3.461)

0.070

Donor type

0.910 (0.473–1.751)

0.777

1.070 (0.559–2.047)

0.839

0.851 (0.440–1.643)

0.630

1.200 (0.393–3.667)

0.748

Mismatched HLA loci

0.943 (0.561–1.587)

0.827

1.146 (0.731–1.797)

0.552

1.036 (0.609–1.764)

0.896

1.626 (0.849–3.113)

0.143

Blood type

1.179 (0.789–1.761)

0.422

1.166 (0.798–1.704)

0.427

1.070 (0.693–1.651)

0.761

0.911 (0.472–1.761)

0.783

MNC count

1.373 (0.583–3.235)

0.468

1.015 (0.456–2.259)

0.972

1.358 (0.551–3.343)

0.506

0.669 (0.173–2.589)

0.561

CD34 + cells count

0.595 (0.200–1.771)

0.351

0.612 (0.229–1.632)

0.326

0.678 (0.225–2.048)

0.491

0.614 (0.130–2.903)

0.539

EBMT risk score

2.653 (1.366 -5.152)

0.004

2.637 (1.438–4.835)

0.002

2.383 (1.219–4.662)

0.011

3.998 (1.291–12.379)

0.016

aGVHD

1.290 (0.548–3.038)

0.560

1.083 (0.494–2.373)

0.843

1.611 (0.648–4.007)

0.305

1.190 (0.344–4.114)

0.783-

cGVHD

0.281 (0.083–0.956)

0.042

0.316 (0.108–0.921)

0.035

0.319 (0.093–1.096)

0.070

0.693 (0.179–2.681)

0.595

Infection

3.887 (1.635–9.239)

0.002

3.100 (1.413–6.803)

0.005

4.944 (1.944–12.574)

0.001

1.922 (0.541–6.827)

0.312-

UCB

0.409 (0.173–0.967)

0.035

0.376 (0.171–0.826)

0.011

0.409 (0.165–1.009)

0.045

0.169 (0.043–0.657)

0.004

  1. Bolded variable represented P < 0.10
  2. OS, overall survival; PFS, progression-free survival; TRM, transplant-related mortality; HR, hazard ratio; CI, confidence interval; HLA, human leukocyte antigen; MNC, mononuclear cell; EBMT, the European group for blood and marrow transplantation; GVHD, graft versus host disease. Factors with P > 0.10 were excluded