Variable | OS | PFS | TRM | Relapse | ||||
---|---|---|---|---|---|---|---|---|
HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | P value | |
Age | 1.030 (1.002–1.058) | 0.036 | 1.839 (1.037–3.259) | 0.037 | 1.692 (0.885–3.237) | 0.112 | 1.706 (0.689–4.223) | 0.248 |
Gender | 0.089 (0.340–1.922) | 0.631 | 0.859 (0.390–1.894) | 0.707 | 0.782 (0.314–1.947) | 0.597 | 1.071 (0.309–3.713) | 0.914 |
Height | 1.213 (0.512–2.876) | 0.660 | 0.829 (0.371–1.850) | 0.646 | 1.207 (0.487–2.991) | 0.685 | 0.538 (0.138–2.099) | 0.373 |
Weight | 1.162 (0.489–2.758) | 0.734 | 1.410 (0.633–3.144) | 0.401 | 0.971 (0.395–2.391) | 0.950 | 2.259 (0.582–8.769) | 0.239 |
Disease status | 1.500 (0.957–2.351) | 0.077 | 1.527 (1.015–2.295) | 0.042 | 1.303 (1.047–1.621) | 0.018 | 1.815 (0.951–3.461) | 0.070 |
Donor type | 0.910 (0.473–1.751) | 0.777 | 1.070 (0.559–2.047) | 0.839 | 0.851 (0.440–1.643) | 0.630 | 1.200 (0.393–3.667) | 0.748 |
Mismatched HLA loci | 0.943 (0.561–1.587) | 0.827 | 1.146 (0.731–1.797) | 0.552 | 1.036 (0.609–1.764) | 0.896 | 1.626 (0.849–3.113) | 0.143 |
Blood type | 1.179 (0.789–1.761) | 0.422 | 1.166 (0.798–1.704) | 0.427 | 1.070 (0.693–1.651) | 0.761 | 0.911 (0.472–1.761) | 0.783 |
MNC count | 1.373 (0.583–3.235) | 0.468 | 1.015 (0.456–2.259) | 0.972 | 1.358 (0.551–3.343) | 0.506 | 0.669 (0.173–2.589) | 0.561 |
CD34 + cells count | 0.595 (0.200–1.771) | 0.351 | 0.612 (0.229–1.632) | 0.326 | 0.678 (0.225–2.048) | 0.491 | 0.614 (0.130–2.903) | 0.539 |
EBMT risk score | 2.653 (1.366 -5.152) | 0.004 | 2.637 (1.438–4.835) | 0.002 | 2.383 (1.219–4.662) | 0.011 | 3.998 (1.291–12.379) | 0.016 |
aGVHD | 1.290 (0.548–3.038) | 0.560 | 1.083 (0.494–2.373) | 0.843 | 1.611 (0.648–4.007) | 0.305 | 1.190 (0.344–4.114) | 0.783- |
cGVHD | 0.281 (0.083–0.956) | 0.042 | 0.316 (0.108–0.921) | 0.035 | 0.319 (0.093–1.096) | 0.070 | 0.693 (0.179–2.681) | 0.595 |
Infection | 3.887 (1.635–9.239) | 0.002 | 3.100 (1.413–6.803) | 0.005 | 4.944 (1.944–12.574) | 0.001 | 1.922 (0.541–6.827) | 0.312- |
UCB | 0.409 (0.173–0.967) | 0.035 | 0.376 (0.171–0.826) | 0.011 | 0.409 (0.165–1.009) | 0.045 | 0.169 (0.043–0.657) | 0.004 |