Table 1 Homozygous HLA-A-B-C-DRB1-DQA-DQB1 haplotypes, level of homozygosity within a haplotype and number of blood donors identified among 20,737 blood donors
Haplotype | HLA-A | HLA-B | HLA-C | HLA-DRB1 | HLA-DQA1 | HLA-DQB1 | N | Observed frequency | Expected frequency | Heterozy-gous markers % |
|---|---|---|---|---|---|---|---|---|---|---|
1 | 03:01 | 35:01 | 04:01 | 01:01 | 01:01 | 05:01 | 149 | 0.00718522 | 0.00690815 | 0.12 |
2 | 01:01 | 08:01 | 07:01 | 03:01 | 05:01 | 02:01 | 48 | 0.00231470 | 0.00242061 | 0.41 |
3 | 03:01 | 07:02 | 07:02 | 15:01 | 01:02 | 06:02 | 27 | 0.00130202 | 0.00113331 | 0.64 |
4* | 02:01 | 07:02 | 07:02 | 15:01 | 01:02 | 06:02 | 7 | 0.00033756 | 0.00051551 | 2.11 |
5* | 02:01 | 13:02 | 06:02 | 07:01 | 02:01 | 02:02 | 7 | 0.00033756 | 0.00039721 | 0.67 |
6* | 02:01 | 15:01 | 03:04 | 04:01 | 03:01 | 03:02 | 7 | 0.00033756 | 0.00029789 | 1.23 |
7 | 03:01 | 07:02 | 07:02 | 13:01 | 01:03 | 06:03 | 6 | 0.00028934 | 0.00035215 | 1.62 |
8 | 02:01 | 27:05 | 02:02 | 08:01 | 04:01 | 04:02 | 5 | 0.00024111 | 0.00031656 | 0.01 |
9* F | 02:01 | 51:01 | 15:02 | 09:01 | 03:02 | 03:03 | 5 | 0.00024111 | 0.00013848 | 0.02 |
10 F | 03:01 | 15:01 | 03:03 | 08:01 | 04:01 | 04:02 | 5 | 0.00024111 | 0.00007897 | 0.02 |
11 | 02:01 | 15:01 | 03:03 | 13:01 | 01:03 | 06:03 | 4 | 0.00019289 | 0.00017316 | 2.31 |
12 | 24:02 | 40:01 | 03:04 | 13:02 | 01:02 | 06:04 | 4 | 0.00019289 | 0.00011964 | 0.12 |
13 | 02:01 | 27:05 | 01:02 | 01:01 | 01:01 | 05:01 | 4 | 0.00019289 | 0.00011769 | 1.16 |
14 | 02:01 | 15:01 | 04:01 | 08:01 | 04:01 | 04:02 | 3 | 0.00014467 | 0.00018545 | 0.09 |
15* F | 03:01 | 18:01 | 07:01 | 04:04 | 03:01 | 03:02 | 3 | 0.00014467 | 0.00007943 | 0.02 |
16 | 02:01 | 08:01 | 07:01 | 03:01 | 05:01 | 02:01 | 3 | 0.00014467 | 0.00006399 | 2.21 |
17 F | 31:01 | 18:01 | 07:01 | 15:01 | 01:02 | 06:02 | 2 | 0.00009645 | 0.00013433 | 0.03 |
18 F | 03:01 | 07:02 | 03:04 | 01:01 | 01:01 | 05:01 | 2 | 0.00009645 | 0.00008789 | 2.43 |
19 | 02:01 | 40:01 | 03:04 | 13:02 | 01:02 | 06:04 | 2 | 0.00009645 | 0.00007268 | 2.35 |
20 F | 24:02 | 39:01 | 07:02 | 08:01 | 04:01 | 04:02 | 2 | 0.00009645 | 0.00002717 | 2.90 |
21 F | 02:01 | 15:01 | 04:01 | 15:01 | 01:02 | 06:02 | 2 | 0.00009645 | 0.00000850 | 0.40 |
22 | 02:01 | 44:02 | 05:01 | 12:01 | 05:05 | 03:01 | 1 | 0.00004822 | 0.00007523 | 5.20 |
23 | 68:01 | 08:01 | 07:01 | 03:01 | 05:01 | 02:01 | 1 | 0.00004822 | 0.00006170 | 0.003 |
24 F | 02:01 | 27:05 | 01:02 | 04:08 | 03:03 | 03:01 | 1 | 0.00004822 | 0.00003359 | 0.03 |
25 | 24:02 | 35:01 | 04:01 | 01:01 | 01:01 | 05:01 | 1 | 0.00004822 | 0.00002598 | 0.02 |
26 F | 02:01 | 56:01 | 01:02 | 04:01 | 03:01 | 03:02 | 1 | 0.00004822 | 0.00002582 | 0.01 |
27 | 03:01 | 15:01 | 03:04 | 04:01 | 03:01 | 03:02 | 1 | 0.00004822 | 0.00002199 | 0.06 |
28* F | 31:01 | 51:01 | 01:02 | 13:01 | 03:02 | 03:03 | 1 | 0.00004822 | 0.00002156 | 0.40 |
29 F | 02:01 | 56:01 | 01:02 | 15:01 | 01:02 | 06:02 | 1 | 0.00004822 | 0.00001116 | 0.03 |
30 | 02:01 | 27:05 | 02:02 | 01:01 | 01:01 | 05:01 | 1 | 0.00004822 | 0.00000611 | 6.73 |
31 | 29:02 | 44:03 | 16:01 | 07:01 | 02:01 | 02:02 | 1 | 0.00004822 | 0.00000374 | 0.08 |
32 | 23:01 | 44:03 | 04:01 | 07:01 | 02:01 | 02:02 | 1 | 0.00004822 | 0.00000318 | 0.25 |
33 | 32:01 | 40:02 | 03:04 | 14:02 | 05:03 | 03:01 | 1 | 0.00004822 | 0.00000300 | 0.14 |
34 | 03:01 | 15:01 | 03:03 | 13:02 | 01:02 | 06:04 | 1 | 0.00004822 | 0.00000290 | 0.01 |
35 | 32:01 | 35:01 | 04:01 | 04:01 | 03 | 03:01 | 1 | 0.00004822 | 0.00000218 | 0.07 |
36 | 11:01 | 44:02 | 05:01 | 04:04 | 03:01 | 03:02 | 1 | 0.00004822 | 0.00000146 | 0.03 |
37 | 32:01 | 44:02 | 05:01 | 15:01 | 01:02 | 06:02 | 1 | 0.00004822 | 0.00000127 | 0.06 |
38 | 11:01 | 35:01 | 03:03 | 08:01 | 04:01 | 04:02 | 1 | 0.00004822 | 0.00000048 | 0.06 |
39 | 25:01 | 08:01 | 07:01 | 03:01 | 05:01 | 02:01 | 1 | 0.00004822 | 0.00000008 | 0.08 |
40 | 26:01 | 40:02 | 03:04 | 08:01 | 04:01 | 04:02 | 1 | 0.00004822 | 0.00000004 | 0.12 |
41 | 02:01 | 51:01 | 15:02 | 04:01 | 03:01 | 03:02 | 1 | 0.00004822 | 0.00000001 | 0.03 |