Table 2 10 most common homozygous HLA-A-B-C-DRB1-DQA1-DQB1-DPB1 haplotypes, level of homozygosity in the MHC region by haplotype and number of blood donors identified among 20,737 blood donors
Haplotype | HLA-A | HLA-B | HLA-C | HLA-DRB1 | HLA-DQA1 | HLA-DQB1 | HLA-DPB1 | N | Observed frequency | Expected frequency | Heterozygous markers % |
|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 03:01 | 35:01 | 04:01 | 01:01 | 01:01 | 05:01 | 04:02 | 71 | 0.00342 | 0.00309 | 0.31 |
2 | 01:01 | 08:01 | 07:01 | 03:01 | 05:01 | 02:01 | 01:01 | 11 | 0.00053 | 0.00061 | 1.70 |
3 | 03:01 | 07:02 | 07:02 | 15:01 | 01:02 | 06:02 | 04:01 | 14 | 0.00068 | 0.00058 | 1.99 |
4* | 02:01 | 07:02 | 07:02 | 15:01 | 01:02 | 06:02 | 04:01 | 2 | 0.00010 | 0.00005 | 5.85 |
5* | 02:01 | 13:02 | 06:02 | 07:01 | 02:01 | 02:02 | 04:01 | 7 | 0.00034 | 0.00031 | 1.15 |
6* | 02:01 | 15:01 | 03:04 | 04:01 | 03:01 | 03:02 | 04:01 | 4 | 0.00019 | 0.00024 | 3.43 |
7 | 03:01 | 07:02 | 07:02 | 13:01 | 01:03 | 06:03 | 04:01 | 2 | 0.00010 | 0.00011 | 0.05 |
8 | 02:01 | 27:05 | 02:02 | 08:01 | 04:01 | 04:02 | 03:01 | 4 | 0.00019 | 0.00025 | 0.82 |
9* FER | 02:01 | 51:01 | 15:02 | 09:01 | 03:02 | 03:03 | 04:02 | 4 | 0.00019 | 0.00012 | 0.13 |
10 FER | 03:01 | 15:01 | 03:03 | 08:01 | 04:01 | 04:02 | 03:01 | 4 | 0.00019 | 0.00004 | 0.47 |