Fig. 1

CPP induces morphological changes of HDFs. A The chemical structure of CPP. B Cell viability was determined using the sulforhodamine B (SRB) assay according to the manufacturer’s instructions. HDFs were seeded in 96-well plates and were then treated with 0.1% DMSO (as a control) or with CPP at the indicated concentration for 48 h, after which the SRB assay was used to determine cell viability. C, D HDFs were treated with the small chemical molecule CPP (0, 1, 10 or 20 μM) for 6 days (D6) or 10 days(D10), after which morphological changes of HDFs were examined using an inverted phase contrast microscope (Eclipse TS-100; Nikon, Tokyo). Scale bar: 20 μm