Fig. 7
From: Stability and biosafety of human epidermal stem cell for wound repair: preclinical evaluation
Tumorigenicity of subcutaneously injected EpiSCs in vivo. A Normal saline, EpiSCs, and B16 cells were injected subcutaneously into nude mice. “✕” indicates that there was no tumorigenesis 4 months after normal saline and EpiSC transplantation, and “✓” represents tumor formation on the 12th day after B16 transplantation. B Four months after the operation, the skin of the subcutaneous injection site was stained with HE in the NaCl group and the EpiSC group. C Four months after the operation, the heart, liver, spleen, lung, and kidney were stained with HE in the NaCl group and EpiSC group. Note. The subcutaneous injection site is marked by the red circle, “✕” means no tumor formation, and “✓” means tumor formation