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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: KW-2449 and VPA exert therapeutic effects on human neurons and cerebral organoids derived from MECP2-null hESCs

Fig. 3

Global transcriptional changes in hESCs-derived MECP2-KO organoids. A Heatmap and hierarchical clustering analysis of the significant genes from RNA-seq data. Samples of control (PX330), M8 and M20 were compared. The yellow indicates increased expression of genes, whereas blue stands for the decreased genes compared to PX330. B The volcano plots depicting the gene expression changes for M8 or M20 versus PX330. The upregulated, unchanged and downregulated genes are highlighted in red, gray and green, respectively. C Bar plots showing the top 9 significantly enriched GO terms (biological processes, BP) and the top 8 significantly enriched KEGG pathways of upregulated genes for M8 and M20 versus PX330. The numbers in the right indicate the number of genes with indicated expression changes. D Bar plots showing the top 10 significantly enriched GO terms (biological processes, BP) and the top 8 significantly enriched KEGG pathways of downregulated genes for M8 and M20 versus PX330. The numbers in the right indicate the number of genes with indicated expression changes

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Stem Cell Research & Therapy

ISSN: 1757-6512