Fig. 1

Irradiation configuration with the Small Animal Radiation Research Platform (SARRP) and study of hematuria. In the pictures, the bladder is represented in blue. A Placement of the animal in the SARRP. B Coronal view of the bladder. C Sagittal view of the bladder. D Transverse view of the bladder. E Representation of the isodose distribution in the tissue for a dose of 40 Gy. The bladder is represented in blue and receives 100% of the dose. F Histogram of the dose per volume in the bladder for a dose of 40 Gy. G Experimental design for studies with MSC treatment with a dose of 40 Gy and 12 months follow-up. Injections of 5 millions of MSC are performed at 4.5, 5 and 5.5 months post-irradiation. Euthanasia times are at 6, 8 and 12 months post-irradiation and tissue analyses are performed. Cystoscopies are performed at 6 and 12 months post-irradiation