Fig. 6
From: Dose-specific efficacy of adipose-derived mesenchymal stem cells in septic mice
Dose-related effect of ADSCs on liver transcriptome changes in CLP mice. GO analysis was performed to define biological processes enriched by DEGs between different treatment groups (A) and the unique genes induced by ADSCs1 treatment (B). DEGs involved in interleukin-1 beta production, leukocyte migration and tumor necrosis factor production were visualized by heatmap (C). Heatmap visualization of the expression patterns of 35 hypoxia-inducible genes among ADSCs-responsive genes in the liver, with representative genes marked in red (D). Changes in the expression levels of Vegfa, Slc2a1 and P4ha2 in the liver were validated by RT-qPCR (E). n = 4 in each group. *, p < 0.05, significantly different from the CLP + Vehicle group