Table 2 SYRCLE risk-of-bias assessment for included studies
Number | Author (year) | Author year country | Random sequence generation? | Groups similar at baseline? | Allocation concealed? | Animals randomly housed? | Blinding of caregivers and/or examiners? | Random selection for outcome assessment? | Blinding of outcome assessor? | Incomplete outcome data addressed? | Free from selective outcome reporting? | Free from other bias? |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 2015 | Lee et al. (2015) Republic of Korea [22] | L | U | L | U | L | L | L | L | L | L |
2 | 2019 | Xin et al. (2018) USA [23] | U | U | U | U | L | U | L | L | L | L |
3 | 2019 | Kuang et al. (2019) Germany [24] | L | L | U | L | L | U | U | L | L | L |
4 | 2020 | Xu et al. (2020) China [25] | U | U | U | U | U | U | U | H | U | L |
5 | 2020 | Pan et al. (2020) China [26] | U | L | U | L | U | U | U | H | L | L |
6 | 2020 | Li et al. (2020) China [27] | U | U | U | U | U | U | U | H | U | L |
7 | 2020 | Nalamolu et al. (2020) USA [28] | L | L | L | L | L | L | L | L | L | L |
8 | 2020 | Zhang et al. (2020) China [29] | U | L | U | U | L | L | L | L | L | L |
9 | 2020 | Xia et al. (2020) China [30] | L | L | U | L | U | U | U | U | L | L |
10 | 2020 | Haupt et al. (2020) Germany [31] | L | L | U | U | L | U | U | U | L | L |
11 | 2020 | Wang et al. (2020) Germany [32] | U | U | U | U | U | U | U | H | L | L |
12 | 2020 | Hou et al. (2020) China [33] | L | L | U | L | L | U | L | L | L | L |
13 | 2021 | Barzegar et al. (2021) USA [34] | U | U | U | U | U | U | U | H | L | L |
14 | 2021 | Zhang et al. (2021) China [35] | U | L | U | U | L | L | L | H | L | L |
15 | 2021 | Li et al. (2021) China [36] | L | L | L | L | L | U | L | H | U | L |
16 | 2021 | Feng et al. (2021) China [37] | U | U | U | U | L | L | L | L | L | L |
17 | 2021 | Lv et al. (2021) China [38] | L | L | U | L | U | U | U | L | L | L |
18 | 2021 | Xin et al. (2021) USA [39] | U | U | U | U | L | U | L | L | L | L |
19 | 2021 | Xia et al. (2021) China [40] | L | L | U | L | U | U | U | L | L | L |
20 | 2021 | Zhang et al. (2021) China [41] | U | L | U | U | U | U | U | U | L | L |
21 | 2021 | Hou et al. (2021) China [42] | U | L | U | U | U | U | U | U | L | L |