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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Human umbilical cord mesenchymal stem cells conditioned medium exerts anti-tumor effects on KGN cells in a cell density-dependent manner through activation of the Hippo pathway

Fig. 7

UCMSCs-CM suppresses the malignant phenotype depend on activating the Hippo pathway. KGN cells pretreated with 5 μM XMU-MP-1 and cultured with UCMSCs-CM for 48 h at high (High) and low (Low) density. A The cell viability was examined by CCK-8 assay. B Expression of cyclin D1 and p27 detected by western blot. Full-length blots are presented in Additional file 2: Fig. S8. C The quantitative results showing the relative expression levels of cyclin D1. D The quantitative results showing the relative expression levels of p27. E Expression of Bax and Bcl-2 detected by western blot. Full-length blots are presented in Additional file 2: Fig. S9. F The quantitative results showing the ratio of Bax/Bcl-2. G Representative images of invasion assays. Scale bar, 200 μm. H The quantitative results of invading cell numbers. *P < 0.05, **P < 0.01, ****P < 0.0001. NS No statistical difference

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Stem Cell Research & Therapy

ISSN: 1757-6512