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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: BM-MSCs overexpressing the Numb enhance the therapeutic effect on cholestatic liver fibrosis by inhibiting the ductular reaction

Fig. 2

The transplantation of BM-MSCs overexpressing Numb inhibits the hepatic inflammatory response and liver fibrosis. a Expression of Numb in the livers from a healthy population (n = 10) and patients with PBC (n = 20): Numb immunostaining (× 200) and its positive area. b Experimental flow chart. c Lentivirus-transfected BMSCs (× 100) and Numb protein and mRNA expression levels in BM-MSCs overexpressing Numb (Full-length blot is presented in Additional file 2: Fig. 1). d H&E staining (× 200) and Sirius red collagen staining (× 100). e α-SMA immunostaining (× 200). f Serum levels of biochemical markers. g Hyp content in liver tissue. h α-SMA immunoblotting bands, gray-level integration and mRNA expression (n = 6/per group) (Full-length blot is presented in Additional file 2: Fig. 2). i The mRNA levels of cytokines related to liver fibrosis (n = 6/per group). *P < 0.05; **P < 0.01

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Stem Cell Research & Therapy

ISSN: 1757-6512