Fig. 4

BM-MSCs^Numb-KD transplantation promotes the hepatic inflammatory response and liver fibrosis. a Experimental flow chart. b Lentivirus-transfected BMSCs (× 100) and Numb protein and mRNA expression levels in BM-MSCs with knockdown of Numb (Full-length blot is presented in Additional file 2: Fig. 8). c H&E staining (× 200) and Sirius red collagen staining (× 100). d α-SMA immunostaining (× 200). e Serum levels of biochemical markers and f the Hyp content in liver tissues. g α-SMA immunoblotting bands, gray-level integration and mRNA expression (n = 6/per group) (Full-length blot is presented in Additional file 2: Fig. 9); h The mRNA expression levels of TGF-β1, TNF-α, Col(1), and Col(4). *P < 0.05; **P < 0.01