Fig. 5

BM-MSC^Numb-KD transplantation activates Notch signaling in the livers of CLF rats and induces the differentiation of these cells into BECs. a Numb, RBP-Jκ and Hes1 immunostaining (× 400). b Protein and mRNA expression levels of Numb, RBP-Jκ, and Hes1 (n = 6/per group) (Full-length blots are presented in Additional file 2: Figs. 10–12). c CK7 and CK19 immunostaining (× 200). d Protein and mRNA expression levels of CK7 and CK19 (Full-length blots are presented in Additional file 2: Figs. 13 and 14). e CK7/EGFP (labeling BM-MSC^KD-EV and BM-MSC^Numb-KD) immunofluorescence costaining (× 200), and the costaining area ratio of CK7/EGFP. f CK19/EGFP immunofluorescence costaining (× 200), and the costaining area ratio of CK19/EGFP. *P < 0.05; **P < 0.01