Fig. 2

Protective effects of PGE2-MSC treatment against LPS-ALI in mice. A Schematic of the priming of PGE2-MSCs and study design. B Representative BLI of mice transplanted with PGE2-MSCs and MSCs for in vivo monitoring. C Quantitative analysis of BLI signals showed that the survival of PGE2-MSCs were better than those of MSCs. Data are expressed as the mean ± SEM. *P < 0.05. D Kaplan–Meier survival curves of LPS-induced ALI mice after administration of PGE2-MSCs, MSCs and PBS for 5 days. E Body weight was measured daily to observe the severity of ALI. F, G Total cell count and total protein concentration in BALF of LPS-induced ALI mice with or without MSC treatment at 24 h 48 h and 72 h. Data are presented as the mean ± SEM. *P < 0.05 vs ALI;^#P < 0.05 vs PBS; ^&P < 0.05 vs MSCs