Research progress of engineered mesenchymal stem cells and their derived exosomes and their application in autoimmune/inflammatory diseases

Zhu, Xueqing; Ma, Dan; Yang, Baoqi; An, Qi; Zhao, Jingwen; Gao, Xinnan; Zhang, Liyun

doi:10.1186/s13287-023-03295-7

Stem Cell Research & Therapy

Table 2 Application of engineered MSCs and exosomes in autoimmune diseases

From: Research progress of engineered mesenchymal stem cells and their derived exosomes and their application in autoimmune/inflammatory diseases

Disease	Cells/exosomes	Engineering technology	Results	References
RA	MSCs	Genetically modified MSCs to overexpress HsTNFR2	Prevented arthritis symptoms	[121]
	MSCs	Genetically modified MSCs to overexpress HGF	Alleviated joint inflammation in CIA mice	[122]
	MSCs	Gene transfer of etanercept-loaded micro circular plasmids to MSCs by electroporation	Improved arthritis symptoms in CIA mice	[123]
	hMSCs	Epigenetic modification of hMSCs to enhance cellular function	Enhanced immune suppression	[124]
	MSCs	MTX- and TGFβ1-loaded hydrogels combine with MSCs	Anti-inflammatory	[125]
			Promoted cartilage differentiation of MSCs
	MSC-Exos	Surface modification of MSC-Exos by metabolic glycoengineering	Promoted polarization of macrophages and reduced the activity of pro-inflammatory cells at the inflammatory site in CIA mice	[158]
	Exos	Surface modification of MSC-Exos to establish targeted drug delivery system	Alleviated joint inflammation in CIA mice	[159]
SLE	MSCs	Lentiviral transfection of MSCs to overexpress IL-37	Inhibition of inflammatory factors	[132]
			Relieved symptoms in lupus model mice
OA	MSCs	3D culture of MSCs	Reduced inflammation, fibrosis, and cartilage degradation in vivo and in vitro	[138]
	MSCs	Epigenetically reprogrammed MSCs	Increased in vitro proliferation ability and improve articular chondrocyte differentiation	[139]
	BMSC-Exos	Hydrophilic Hydrogel combined with Exos	Promoted cartilage regeneration and remodeling	[160]
	MSC-EVs	MSC-EVs modified by PPD to changes its surface charge	Increased absorption, penetration and retention in cartilage	[161]
IBD	MSCs	Genetically modified MSCs to overexpress ICAM-1	Enhance immune regulation and reduce colon tissue damage	[147]
	MSCs	ICAM-1-coated MSCs	Promotes adhesion to endothelial cells	[151]
	MSCs	VCAM-1-coated MSCs	Prolonged survival in IBD mice	[152]
	MSC-EVs	Lentiviral transfection of MSC-EVs to overexpress PD-1	Targeted lesions for immune regulation	[163]
	EVs	Designed a DNA aptamer to enhance EVs mRNA delivery	Efficiently induced browning of white adipocytes	[164]
			Promoted anti-inflammatory in IBD mice

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ISSN: 1757-6512

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