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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Adipose-derived stem cells promote the repair of chemotherapy-induced premature ovarian failure by inhibiting granulosa cells apoptosis and senescence

Fig. 5

Apoptosis and senescence of granulosa cell decreased after ADSC transplantation. The IHC staining results revealed that the proliferation (A) and apoptosis (B) were increased in rats with POF and decreased in rats treated with ADSCs. Live and dead cell staining (C) and SA-β-gal staining (D) showed that CTX increased the cell death and senescence of granulosa cells, and co-cultured with ADSCs reduced the death and senescence. E Ki67 staining of CTX-treated KGN cell and ADSCs co-cultured cells. F p21 staining of CTX-treated KGN cells and ADSCs co-cultured cells

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Stem Cell Research & Therapy

ISSN: 1757-6512