Efficacy of mesenchymal stem cell therapy in rodent models of radiation-induced xerostomia and oral mucositis: a systematic review

Table 1 Characteristics of animal studies

Author/years	Country	Study designs	Species	Strain	Sex	Total number of animals	IR Types	Irradiation dose	Follow-up time
Radiation-induced xerostomia
An et al. 2015 [39]	Korea	RCT	Mice	C3H	Female	105	X-ray	15 Gy	16W
Kim et al. 2019 [40]	Korea	RCT	Mice	C57BL/6	Female	45	Radioiodine	0.01 mCi/g	16W
Choi et al. 2018 [15]	Korea	RCT	Mice	C3H	Female	140	X-ray	15 Gy	16W
Shin et al. 2018 [41]	Korea	RCT	Mice	C3H	Female	12	X-ray	15 Gy	12W
Lim,et al. 2013 [30]	Korea	RCT	Mice	C57BL/6	Unkown	24	X-ray	15 Gy	12W
Saylam et al. 2017 [43]	Turkey	RCT	Rats	Wistar albino	Female	60	Radioiodine	2 mCi	6 M
Lim et al. 2013 [42]	Korea	RCT	Mice	C3H	Female	60	X-ray	15 Gy	12W
Mulyani et al. 2019 [44]	Indonesia	RCT	Rats	Wistar	Male	40	X-ray	15 Gy	4W
Radiation-induced oral mucositis
Maria et al. 2016 [38]	Canada	RCT	Mice	BALB/c	Male	45	X-ray	18 Gy	21D
Elsaadany et.al.2017 [13]	Egypt	RCT	Rats	Albino	Male	60	X-ray	13 Gy	7D
Schmidt et al. 2014 [14]	German	RCT	Mice	C3H/Neu	Male	50	X-ray	15 Gy	3W
Shen et al. 2018 [35]	China	RCT	Mice	C57	Male	18	X-ray	16 Gy	10D

ISSN: 1757-6512