Efficacy of mesenchymal stem cell therapy in rodent models of radiation-induced xerostomia and oral mucositis: a systematic review

Table 2 Mesenchymal stem cell characteristics

Author/Years	Sources	Control group	Manipulation	Dose	Volume	Delivery route
Radiation-induced xerostomia
An et al. 2015 [39]	hAdMSCs	PBS	Hypoxia	1 × 105	500μl	Intravenous injection
Kim et al. 2019 [40]	hAdMSCs	PBS	Non	1 × 105	Unkown	Intraglandular injection
Choi et al. 2018 [15]	hAdMSCs	PBS	Matrix	1 × 105	20 μl	Intraglandular injection
Shin et al. 2018 [41]	hAdMSCs	PBS	Hypoxia	2 × 105	10 μl	Intraglandular injection
Lim et al. 2013 [30]	BM-MSCs	PBS	Non	1 × 105	15 μl	Intraglandular injection
Saylam et al. 2017 [43]	AdMSCs	PBS	Non	2 × 106	Unkown	Intraperitoneal injection
Lim et al. 2013 [42]	AdMSCs	PBS	Non	1 × 106	Unkown	Intravenous injection
Mulyani et al. 2019 [44]	BM-MSCs	PBS	Hypoxia	Unkown	Unkown	Unkown
Radiation-induced oral mucositis
Maria et al. 2016 [38]	AdMSCs	PBS	Non	2.5 × 106	500 μl	Intraperitoneal injection
Elsaadany et al. 2017 [13]	BM-MSCs	PBS	Non	1 × 107	0.2 ml	Intravenous injection
Schmidt et al. 2014 [14]	BM-MSCs	PBS	Non	6 × 106	Unkown	Intravenous injection
Shen et al. 2018 [35]	hBM-MSCs	PBS	Genetic	Unknown	Unknown	Intravenous injection

AdMSCs Adipose tissue-derived mesenchymal stem cells; BM-MSCs Bone marrow-derived mesenchymal stem cells; PBS Phosphate buffered saline

ISSN: 1757-6512