Fig. 5
From: A beginner’s guide on the use of brain organoids for neuroscientists: a systematic review
Small molecule and growth factor used in guided dorsal forebrain and ventral forebrain protocols. Molecules and factors are scored by their uses in EB formation and induction of neuroectoderm, proliferation of the neural tissues, or differentiation and maturation of the organoids. Molecules are grouped by their pathways and determined to exert an inhibitory (blue) or stimulating (red) effect on different pathways. Abbreviations top to bottom, left to right, form: formation, Induc: induction, Prolif: proliferation, Diff: differentiation, Mat: maturation, SB431: SB-431542/3, Activin A: Recominbant Human/ Mouse/ Rat Activin A, Dorso: dorsomorphine, LDN: LDN-193189, IWR-1e: IWR-1(endo), CHIR: CHIR99021, Cyclo: cyclopamine, SAG: smoothened agonist, Purmor: purmorphamine, SHH: Recombinant SHH, RA: retinoic acid, Allepreg: allepregnanolone, Ketoco: ketoconazole, Clema: clemastine, GSK: GSK2656157, HGF: hepatocyte growth factor, IGF: Insulin-like growth factor, PDGF: PDGF-AA, AA: ascorbic acid, Doco: docosahexaenoic acid