Table 6 Advantages and limitations of the cerebral, dorsal forebrain, and ventral forebrain organoid models
From: A beginner’s guide on the use of brain organoids for neuroscientists: a systematic review
Model | Advantages | Limitations |
|---|---|---|
Cerebral organoids | Extracellular matrix support for neuroectoderm expansion | Spontaneous differentiation of different brain regions |
Presence of multiple brain region characteristics | Primarily dorsal forebrain identity | |
Heterogeneous in size | ||
Dorsal forebrain organoids | Specific regional identities | No extracellular matrix embedment |
Homogeneous in size | ||
Possibility to fuse with other regional organoids to create more complex systems | ||
Ventral forebrain organoids | Specific regional identities | In most cases, lack of embedded extracellular matrix support |
Homogeneous in size | ||
Possibility to fuse with other regional organoids to create more complex systems |