Fig. 5

Skin wound healing accelerated by h-sEV-AT. a Schematic view of the experimental operation process. Full-thickness skin defects were made, and h-sEV-AT was injected every 4 days. b Representative digital photographs of wound areas on day 0, day 4, day 6, day 8, day 12, and day 16. c Pattern graphs of wound areas were established for each time point. The dotted circles pointed out the initial wounds, and the colored parts pointed out the wound areas at different time points. d The percentage of wound areas in initial wounds was analyzed (n = 4). The significance was tested with an unpaired two-tailed Student’s t test. **p < 0.01, ***p < 0.001, ****p < 0.0001