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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: iPSC-derived cells lack immune tolerance to autologous NK-cells due to imbalance in ligands for activating and inhibitory NK-cell receptors

Fig. 1

Construction of the isogenic cell model. A Schematic illustration of approaches used in this study. B Schematic illustration of gRNA target site in B2M gene and deletions in B2M alleles in ΔiPSC-B. C Flow cytometry analysis of B2M and HLA-ABC expression in iPSC-B and ΔiPSC-B with and without IFNγ-treatment. D Schematic diagram of the experimental protocol for iPS-fibro differentiation. E Morphology of fibroblasts and iPS-fibro (Scale bars, 50 μm). H Representative flow cytometry analysis of CD73, CD90, and CD105 (fibroblast markers) expression in iPS-fibro-B and ΔiPS-fibro-B

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Stem Cell Research & Therapy

ISSN: 1757-6512