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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: iPSC-derived cells lack immune tolerance to autologous NK-cells due to imbalance in ligands for activating and inhibitory NK-cell receptors

Fig. 4

Gene expression profiling of dermal fibroblasts and isogenic iPSC-derivatives. A The PCA plots clearly separates 3 types of samples: undifferentiated iPSCs, parental fibroblasts, and iPSC-derived fibroblast-like cells (iPS-fibro). B The correlation matrix demonstrating the high degree of similarity between human fibroblasts and iPS-fibro. Samples obtained in this study are indicated in red. C Transcriptome profiles were used to analyze expression of activating and inhibitory NK-cell ligands, as well as adhesion molecules in dermal fibroblasts and iPS-fibro. The expression values of each gene in a row are normalized by a row Z-Score

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Stem Cell Research & Therapy

ISSN: 1757-6512