Fig. 4
From: Application of mesenchymal stem cell sheet for regeneration of craniomaxillofacial bone defects
Possible restorative properties of MSC sheets in rats with BRONJ disease. Like MSC differentiation properties, the paracrine activity of MSCs within the sheet structure is an important factor to accelerate osteogenesis. It is believed that simultaneous activation of angiogenesis and osteogenesis by MSC sheet is critical to yield better regenerative outcomes. The release of VEGF and HGF promotes angiogenesis while RANKL secretion can orient the osteoclast precursor cells into osteoclasts and improves bone remodeling in rats with BRONJ disease (Designed by Photoshop version CS6)