Fig. 5
From: Application of mesenchymal stem cell sheet for regeneration of craniomaxillofacial bone defects
Xenogeneic transplantation of human umbilical cord MSC (hUC-MSC) sheets to immuno-deficient mice (a–g). H & E staining indicates the formation of numerous vascular units in mice that received xenogeneic hUC-MSC sheets (b and c) compared to the control group (a). The transplantation area is indicated with local vascularization (d). Immunofluorescence images confirmed that hUC-MSC sheets produce HGF on days 1 and 10 after being transplanted into the target sites within the cutaneous tissue (f and g). Black arrows = transplanted hUC-MSC sheet; blue arrows = blood vessels. Scale bars in panels a and b = 100 µm; scale bars in panels c, f and g = 50 µm; scale bars in panels d and e = 0.5 cm. Copyright with permission [51] 2019, Scientific reports