Tissue engineering modalities in skeletal muscles: focus on angiogenesis and immunomodulation properties

Table 5 Click chemistry for the fabrication of hydrogels

Type of click reaction	Functional group	Advantages	Disadvantages	Refs.
Azide-Alkyne reaction	Azide + alkyne	Bio-orthogonal injectable	High-temperature process Prolong gelation process	[326]
Diels–Alder reaction	Diel + Alkyne	No catalyst necessity Stereoselectivity	Prolong gelation process Non-injectable	[208]
Thiol-ene reaction	Thiol + alkene	Fast gelation process Oxygen and water resistance	Radical formation Accelerator requirements	[327]
Schiff base reaction	Amine + aldehyde	No cross-linker necessity Injectability	The unwanted reaction between aldehyde and amine groups in other molecules	[328]

ISSN: 1757-6512