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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Overexpression of KCNJ2 enhances maturation of human-induced pluripotent stem cell-derived cardiomyocytes

Fig. 3

Overexpression of KCNJ2 enhances electrophysiological maturation in iPSC-CMs. a–d Representative action potential tracings recorded by single-cell patch clamp from untreated, Vector OE and KCNJ2 OE iPSC-CMs, respectively. Dash lines indicate 0 mV. e Bar graph to compare the number of quiescent and spontaneous beating cells in untreated, Vector OE and KCNJ2 OE iPSC-CMs, respectively. f Bar graph to compare the beating rate in untreated (n = 27 cells), Vector OE (n = 25 cells) and KCNJ2 OE (n = 15 cells) iPSC-CMs, respectively. g–j Bar graphs to compare MDP, APD50, APD90 and Vmax between Vector OE (n = 13 cells) and KCNJ2 OE (n = 40 cells) iPSC-CMs. k Representative action potential tracings recorded by single-cell patch clamp from KCNJ2 OE iPSC-CMs before and after 0.2 mM BaCl2 (IK1 blocker) treatment

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Stem Cell Research & Therapy

ISSN: 1757-6512