Fig. 5

Overexpression of KCNJ2 leads to more stable drug-induced responses in iPSC-CMs. a Representative action potential tracings recorded from Vector OE and KCNJ2 OE iPSC-CMs with acute treatment of 0, 30, 100, 300 and 1000 nM ISO, respectively. b–d Acute effects of ISO on MDP, APD50 and APD90 in Vector OE (n = 5 cells) and KCNJ2 OE (n = 6 cells) iPSC-CMs, respectively. e Representative action potential tracings recorded from Vector OE and KCNJ2 OE iPSC-CMs with acute treatment of 0, 10, 30, 100 and 300 nM E-4031 (hERG-specific blocker), respectively. f–h Acute effects of E-4031 on MDP, APD50 and APD90 in Vector OE (n = 5 cells) and KCNJ2 OE (n = 5 cells) iPSC-CMs, respectively