Fig. 2

ApoVs distribution features in cochlea, liver, lung and kidney after systemic application. a, b, c, d, e representative confocal microscopy images showing 2 h after systemic administration, PKH26-labeled apoVs were distributed in several parts of cochlea (a), including stria vascularis (b), spiral organ (c), corti organ (d) and hair cells (e). a, scale bar = 200 μm. b, c, d, e, scale bar = 50 μm. Phalloidin staining (green) illustrating the hair cell structure. DAPI staining (blue) for nucleus. ①②③represented the same view of different magnification. f, g, h, i representative confocal microscopy images showing distribution of apoVs in hair cells (f), liver (g), lung (h) and kidney (i) at several time points after systemic application. f, scale bar = 50 μm. g, h, i scale bar = 200 μm. DAPI staining (blue) for nucleus