Fig. 3

ApoVs restored noise-induce hearing loss and reduced the loss of outer hair cells. a schematic diagram indicating the protocol for in vivo experiments. b, c, d auditory brainstem response (ABR) measurements showing the auditory threshold shifts of each group at 8 kHz (b), 16 kHz (c), and 32 kHz (d). N = 6–7 per group. Data are presented as individual point with means ± SD. e a cytocochleogram showing the differences in the number of lost OHCs. N = 6–7 per group. * represent the p value between Noise and Noise + apoVs group. f representative confocal microscopy images of the basilar membrane showing the differences in OHCs in apex, middle and base turn of each group. N = 6–7 per group. Scale bar = 50 μm. Data are presented as means ± SD. *p < 0.05, **p < 0.01, ***p < 0.001