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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Functions and regulatory mechanisms of resting hematopoietic stem cells: a promising targeted therapeutic strategy

Fig. 4

Structure and function of the bone marrow hematopoietic niche. The bone marrow hematopoietic niche is the spatial location and physiological microenvironment for the survival and self-renewal of hematopoietic stem cells, which is mainly composed of blood vessels, nerve, mesenchymal stem cells and endothelial cells. It maintains a dynamic balance between self-renewal and differentiation of stem cells. Regulatory T cells are located in bone marrow and protect hematopoietic stem cells from immune attack. (It is original by the author, the components in this figures were created with BioRender.com)

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Stem Cell Research & Therapy

ISSN: 1757-6512