Table 1 Clinical trials of cell sheets from various sources for the repair of various tissues

Heart

End-stage DCM patients with LVAS

Autologous myoblasts

4 sheet layers

Osaka University Graduate School of Medicine

[19]

Severe heart failure (ICM and DCM)

Autologous myoblasts

3‒4 sheet layers

Osaka University Graduate School of Medicine

[15, 20, 21]

Pediatric heart failure

Autologous myoblasts

1 sheet layer

Osaka University Graduate School of Medicine

[16]

Ischemic cardiomyopathy

Allogeneic iPS-derived cardiomyocytes

Unreported

Osaka University Graduate School of Medicine

[22]

Eye

Unilateral corneal epithelial stem cell deficiency

Autologous corneal epithelial cells

Multi-cell layers

Keio University School of Medicine Graduate School of Medicine, The University of Tokyo

[23, 24]

Limbal stem-cell deficiency

Autologous oral mucosal epithelial cells

Multi-cell layers

Osaka University Graduate School of Medicine Tohoku University Graduate School of Medicine Graduate School of Medicine, The University of Tokyo Ehime University Graduate School of Medicine

[25]

iPS-derived corneal epithelial cells

Unreported

Osaka University Graduate School of Medicine

[26]

Intractable keratoconjunctival disease

Autologous oral mucosal epithelial cells

Unreported

Kyoto Prefectural University of Medicine

[27]

Exudative age-related macular degeneration

Autologous iPS-derived RPE cells

1 sheet layer

RIKEN

[28]

Esophageal

Preventing strictures after ESD

Autologous oral mucosal epithelial cells

4‒5 cell layers

Nagasaki University Hospital Tokyo Women’s Medical University

[29,30,31]

Preventing anastomotic re-stricture after repair of congenital esophageal atresia

Autologous oral mucosal epithelial cells

Unreported

National Center for Child Health and Development

[32]

Cartilage

Cartilage regeneration

Autologous chondrocytes

3 sheet layers

Tokai University School of Medicine

[33]

Allogeneic chondrocytes

3 sheet layers

Tokai University School of Medicine

[34]

Periodontal

Periodontal regeneration

Autologous periodontal ligament cells

3 sheet layers

Tokyo Women’s Medical University

[35]

Allogeneic periodontal ligament-derived mesenchymal stromal cells

Unreported

Tokyo Medical and Dental University

[36]

Ear

Middle ear mucosal regeneration

Autologous nasal mucosal epithelial cells

Multi-cell layers

The Jikei University School of Medicine

[37, 38]

Lung

Sealing of lung air leaks

Autologous dermal fibroblasts

1‒3 cell layers

Tokyo Women’s Medical University

[39]