Fig. 1
From: Therapeutic potential of MSCs and MSC-derived extracellular vesicles in immune thrombocytopenia
Phenotype and function of MSCs in healthy individuals and ITP patients. MSCs were involved in platelet production by interacting with immune cells, including ① inhibition of mDC maturation; ② regulation of the ratio of T lymphocyte subsets; ③ inhibition of lymphocyte proliferation; ④ inhibition of antibody release from B cells; and ⑤ promotion of platelet production from megakaryocyte maturation. The function of ITP-MSCs was impaired, mainly by: ⑥ increased G0/G1 cells with restricted proliferation; ⑦ increased apoptosis; ⑧ decreased concentration of CXCL12, which may contribute to reduced ability of megakaryocytes to migrate from the bone marrow sinus to the blood sinus; ⑨ increased release of pro-inflammatory cytokines; ⑩ broad and flattened appearance; ⑪ increased apoptosis of MSCs due to complement deposition. Ps: copyright permission is not applicable