Targeting the neural stem cells in subventricular zone for the treatment of glioblastoma: an update from preclinical evidence to clinical interventions

Table 1 Preclinical evidence of SVZ as a therapeutic target for GBM

Researcher	Object of study	Size of study	Methods	Result	References
Carla et al.	Dogs	32	Radiotherapy	Contacting the SVZ is more malignant and increases the risk of GBM progression	[54]
An et al.	CELLS and nude mice	–	U251 and normal NSCs co-culture	Normal NSCs possessed an anti-glioma property	[55]
Li et al.	Cells	–	U87 and normal NSCs/NPCs co-culture	NSCs/NPCs had inhibitory effects on the growth and invasion of U87 glioma in vitro	[56]
Ehtesham et al.	Cells and mice	–	Stereotactically inoculated co-cultured cells in the right corpus striatum	IL-12-secreting NSCs prolong survival	[59]
Benedetti et al.	Mice	–	Stereotactically inoculated co-cultured cells in the left striatum	IL-4- secreting NSCs had anti-tumor effect	[61]

SVZ subventricular zone, GBM glioblastoma, NSCs neural stem cells, NPCs neural precursor cells

ISSN: 1757-6512