Table 1 The animal model of premature ovarian failure (POF)
Method of model | Animal | Method of administration | Dosage of administration | Advantages | Disadvantages | The model from References |
|---|---|---|---|---|---|---|
CTX | Wistar rat (180–200 g) | Ip: 14 days | 1st: 50 mg/kg; 2–14 th: 8 mg/kg | The most common model; the operation is simple | Myelosuppression and bleeding | [21] |
SD rat (150 g) | Ip: 14 days | 1st: 50 mg/kg; 4–15 th: 5 mg/kg | [23] | |||
SD rat (8 weeks) | Ip: 14 days | 1st: 50 mg/kg; 2–14 th: 5 mg/kg | [24] | |||
TG | SD rat (220–250 g) | Ig: 70 days | For 10 weeks: 40 mg/kg/days | High safety | Long molding time | [10] |
CTX + BF | Wistar rat (180–220 g) | Ip (CTX) + ih (BF) | 1st: CTX:120 mg/kg + BF 12 mg/kg | Simple operation, short cycle, only a single dose | – | [25] |
CIS | SD rat (180–250 g) | Ip: 6 days | 2 mg/kg, Daily, 6 days | Low-cost, short cycles, low mortality | The lethal dose (50) was 7.4 mg/kg | [22] |
SD rat (320 ± 10 g) | Ip: 10 days | 1.5 mg/kg, Daily, 10 days | [26] | |||
DOX | ICR mice (7–8 weeks) | Ip: 7.5 mg/kg, | Single dose | The operation is simple | The model success rate is uncertain | [11] |
ZP3 glycoproteins | BALB/c mice (18–22 g) | SI 1st and 14 th | 1st: 0.16 mg/mouse 14th: 0.16 mg/mouse | Short cycle, high survival rate of mice (100%), and the high success rate (80–90%) | – | [27] |
BALB/c mice (7–8 weeks) | SI 1st and 14 th | 1st: 0.16 mg/mouse 14th: 0.16 mg/mouse | [28] | |||
OA + FIA | SD rat (8  weeks) | SI | 3 times, once every 10 days. OA:FIA = 1: 1 | – | This method is rarely used | [13] |
Thymus removing | BALB/c mice | Surgery | Removing the thymus of 3-day-old neonatal mice | 90% developed autoimmune ovaritis and POF | Thymectomy for newborn mice is difficult to operate and has a high mortality rate | [14] |
Sound-light-electricity stimulation | SD rat (200–220 g) | For 20 days, 5 times per day | The acousto, optical, and electrical stimuli for 20 days | it is consistent with known major causative agents of human POF, and pathogenic pathways and pathological changes are like clinical observations | The success rate of the model is low and large samples are needed | [15] |
CUMS | Wistar (~ 200 g) | For 35 days | Alternating daily fasting and water deprivation, forced swimming, noise interference, and plantar electrical stimulation | [16] | ||
GAL | SD rat (Born 35Â days) | Food pellet: 19 days | Food pellet with 35% galactose: from 3 days of conception continuing through weaning of the litters (21Â days), the adult offspring were POF | Success rate:63% | The period is relatively long | [18] |
D-GAL | Mice (7–8  weeks ) | SI: for 42 days | Daily with d-gal (200 mg/kg/day) | The process of establishing the model is simple | [20] |