Table 2 Common evaluation index of different POF animal models
POF model | Body weight | Hormone | Biomarkers of granulosa cells | Fertility | The model from references | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
AMH | FSH | LH | E2 | Ki67 | Bcl2 | Bax | Caspase (3/9) | FSHR | Number of litters produced | |||
CTX | / | ↓ | ↑ | ↑ | ↓ | ↓ | ↓ | ↑ | ↑ | ↓ | ↓ | |
VCD | ↓ | ↓ | / | / | ↑/↓ | / | / | / | / | / | / | [31] |
CIS | ns | / | / | / | ↓ | / | / | / | ↑ | / | / | [22] |
DOX | / | / | / | / | / | / | / | / | ↑ | / | / | [11] |
GAL | / | / | ↑ | / | ↓ | / | / | / | / | / | / | [18] |
pZP3 | ↓ | ↓ | ↑ | ↑ | ↓ | / | / | / | / | ↓ | / | [35] |
OA + FIA | ↓ | ↓ | / | / | ↓ | / | ↓ | / | ↑ | ↓ | / | [13] |
HFHS | / | / | / | / | ↓ | / | / | / | / | ↓ | / | [37] |
POF model | Ovary | Follicles count | The model from references | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ovary size | Ovary weight | Estrous cycle | Corpus luteum | Ovulation number | Abnormal ovulation | Pro-follicles | Pri-follicles | Snd-follicles | Antral follicle | Atresia follicle | Apoptotic follicles | ||
CTX | / | ↓ | - | ↓ | ↓ | ↑ | ↓ | ↓ | ↓ | ↓ | ↑ | ↑ | |
VCD | ↓ | / | - | / | / | / | ↓ | ↓ | ↓ | / | ↑ | / | [31] |
CIS | / | / | / | / | / | / | ↓ | ↓ | ↓ | ↓ | / | / | [22] |
DOX | ↓ | ↓ | / | / | / | / | ns | ns | ns | ns | ns | ns | [11] |
GAL | / | / | / | / | / | / | / | / | / | ↓ | / | / | [18] |
pZP3 | / | ↓ | - | / | / | / | ↓ | ↓ | / | ↓ | / | ↑ | [35] |
OA + FIA | / | / | / | ↓ | / | / | ↓ | ↓ | ↓ | ↓ | ↑ | / | [13] |
HFHS | / | / | / | / | / | / | / | / | / | ↓ | / | ↑ | [37] |