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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Side population cells derived from hUCMSCs and hPMSCs could inhibit the malignant behaviors of Tn+ colorectal cancer cells from modifying their O-glycosylation status

Fig. 3

The expression of Tn antigen on CRC cells before and after co-cultured with SP-MSCs and HUVECs. a Tn antigen expression in LS174T-Tn−, LS174T-Tn+, HT-29-Tn−, and HT-29-Tn+ cells in different co-cultured systems was analyzed by FCM. SP-hUCMSCs and SP-hPMSCs but not HUEVCs could reduce even to abolish Tn antigen expression in LS174T-Tn+ and HT-29-Tn+ cells. b The percentage of Tn+ cells in LS174T-Tn−, LS174T-Tn+, HT-29-Tn−, and HT-29-Tn+ cells in different co-cultured systems. c The levels of Tn antigen represented by mean fluorescence intensive (MFI) in LS174T-Tn−, LS174T-Tn+, HT-29-Tn−, HT-29-Tn+ cells in different co-cultured systems. SP-hUCMSCs and SP-hPMSCs but not HUEVCs could reduce MFI of Tn antigen in LS174T-Tn+ and HT-29-Tn+ cells. d The absolute number of Tn+ cells in LS174T-Tn−, LS174T-Tn+, HT-29-Tn−, and HT-29-Tn+ cells in different co-cultured systems. Data shown are the mean ± SD of three independent experiments (*P < 0.05, **P < 0.01, and ***P < 0.001)

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Stem Cell Research & Therapy

ISSN: 1757-6512