Fig. 6

Improved cardiac function in hAMSC-treated DMD mice. A Hematoxylin and eosin (H&E) staining of short-axis ventricular cross-sections of 1-year-old control mdx and four-time hAMSC-treated mdx (hAMSC-mdx-4) mice. Original magnification, × 27. Scale bars, 2.5 mm. B High-magnification images represent the boxed regions in the upper A panels. Original magnification, × 200. Scale bars, 500 μm. C Quantification of mononuclear cell infiltration in the short-axis ventricular cross-section (% of total area) of 1-year-old control mdx (n = 6) and hAMSC-treated mdx (hAMSC-mdx-4, n = 6) mice. D Left ventricular fractional shortening (%) was calculated by M-mode echocardiography (WT, n = 4; control mdx, n = 6; hAMSC-mdx-4, n = 5). All data are presented as the mean ± SD, statistical differences are expressed relative to WT (^**P < 0.01) and control mdx (^#P < 0.05 and ^####P < 0.0001) mice (t-test)